Endocrine Abstracts

Context: Hyponatremia is a hormonal disorder of water metabolism encountered in 2% of community dwelling adults in America and in over 15-20% of hospitalized adults.1,2 Hyponatremia leads to increase in risk of falls, cognitive deficits, gait disturbances, loss of independence, prolongation of hospital stay and mortality among older patients admitted to hospitals.3 Objective: To determine in-hospital mortality among older patients ...

65 yr female presented with headaches, heat intolerance and loose stools. She had cerebrovascular accident, osteoporosis and vitiligo. A 24 hr ECG revealed atrial flutter with heart rate upto 117 beats /minute. Her medications include warfarin and bisoprolol.A Thyroid function test (TFT) revealed Free T4 (Ft4): 32 pmol/L (9-19) Free T3: 7.97 pmol/L (3.6–6.5), TSH: 5.7 mU/L (0.35–4.94). Other anterior pituitary function tests were ...

65 yr female presented with headaches, heat intolerance and loose stools. She had cerebrovascular accident, osteoporosis and vitiligo. A 24 hr ECG revealed atrial flutter with heart rate upto 117 beats /minute. Her medications include warfarin and bisoprolol.A Thyroid function test (TFT) revealed Free T4 (Ft4): 32 pmol/L (9-19) Free T3: 7.97 pmol/L (3.6–6.5), TSH: 5.7 mU/L (0.35–4.94). Other anterior pituitary function tests were ...

Objectives: This study was undertaken to ascertain the prevalence of hearing loss (HL) in patients with Type 2 Diabetes (T2DM) and to understand its relationship with diabetic neuropathy.Materials and Methods: Patients between the ages of 30 to 60 years (both ages inclusive) with T2DM were recruited and divided in two groups. Group 1 with moderate to severe distal sensory-motor neuropathy (Michigan Diabetic Neuropathy Score >12) or Group 2 were those...

Background: Obesity in pregnancy is associated with hyperinsulinemia, impaired endothelial function, inflammatory up-regulation and higher risk of placental pathological lesions. However not all obese individuals demonstrate similar metabolic profiles. The present study was designed to investigate placental histopathology in lesions that are associated with maternal and fetal circulation abnormalities, in nonobese and obese women with and without metabolic alterations.<p c...

Background: Most recent cross sectional and longitudinal studies have failed to find an association between cognitive dysfunction and subclinical hypothyroidism. A recent paper from our country however suggested a significant association.Objectives: This study was undertaken to determine the prevelance of cognitive impairement among educated, elderly Indian patients (>60 years) with and without subclinical hypothyroidism.Materi...

Background: A significant percentage of patients with adequately replaced primary hypothyroidism (PH) continue to be symptomatic. Some of these persisting symptoms maybe attributed to non-restoration of neurocognitive functions and psychological well-being.Objectives: To estimate the prevalence of persisting hypothyroid symptoms in patients with PH on biochemically adequate replacement therapy. To correlate persistent symptoms with thyroid hormone levels...

A 60-year-old woman presented to the endocrine clinic with significant hirsutism and male-pattern baldness, progressive since the menopause 5 years earlier. She was otherwise fit and well. Testing revealed an elevated serum testosterone of 14.2 nmol/L. A CT scan revealed a large malignant 19 cm mass arising from the left adnexa, a large fibroid uterus and 2 small masses in the left kidney. Other abdominal organs were normal with no visible ascites. With the presumption of mali...

Context: Studies suggest that 25–40% of men with type 2 diabetes mellitus (T2DM) have hypogonadism. Other studies have estimated that 40–50% of men with T2DM have erectile dysfunction (ED). Some guidelines suggest routine measurements of testosterone in all patients with T2DM.Objectives: To estimate the prevalence of hypogonadism in adult male patients with type 2 diabetes mellitus and symptomatic erectile dysfunction.Met...

Background: Clinical scoring systems were used traditionally in the diagnosis of hypothyroidism before biochemical diagnosis became the norm. There are two well validated clinical scoring systems (Billewicz and Zulewski) for diagnosing hypothyroidism. Both these scores were validated in younger patients with hypothyroidism and may not be useful in older patients. We conducted this study to determine the clinical utility of these two scoring systems among patients over the age ...